Levamisole Hydrochloride (CAS 16595-80-5)

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备用名: Ergamisol; Tramisol; Tramisole; (-)-Tetramisole hydrochloride; Niratic hydrochloride

应用； Levamisole Hydrochloride is an immunomodulatory agent in human micro-and macro vascular endothelial cells

CAS号码: 16595-80-5

纯度: ≥99%

分子量: 240.76

分子式: C₁₁H₁₂N₂S•HCl

补充资料: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.

仅供科研使用。不可用于诊断或治疗。

* 参考分析证明大量特定数据 (包括水含量).

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Levamisole Hydrochloride is an immunomodulatory agent which selectively induces apoptosis in human micro-and macro vascular endothelial cells. In vitro studies suggest that Levamisole Hydrochloride has been used to cause cytotoxic effects in several types of tumor cell lines by potentiating the anti-proliferative effect of 5-fluorouracil. As a result of the cytotoxic effect of Levamisole Hydrochloride DNA fragmentation, release of cytochrome c into the cytoplasm, and the activation of caspase-3 has been observed in cells. Alternate studies have shown that Levamisole Hydrochloride can be used to inhibit the growth of Toxocara canis. Levamisole Hydrochloride has also been shown to increase T-lymphocyte function and macrophage chemotaxis in rheumatic disorder cells. Levamisole Hydrochloride is an activator of AChR. Levamisole Hydrochloride is an inhibitor of Alkaline Phosphatase.

参考文献

1. Carrillo, M. and Barriga, O.O. 1987. Am. J. Vet. Res. 48: 281-283. PMID: 3826867
2. Ramanadham, M. and Nageshwari, B. 2010. J Immunotoxicol. 7: 327-332. PMID: 20860474

外观 :

Powder

物理状态 :

Solid

溶解度 :

Soluble in water (48 mg/ml), methanol, DMSO (100 mM), and ethanol (

保存 :

Store at 4° C

熔点 :

228-230° C

折射率 :

n²⁰_D ~1.71 (Predicted)

光学活性 :

α20/D -126.7°, c = 0.48 in water; α20/D -126°, c = 5 in water

IC50 :

Antiparasitic activity against Ancylostoma caninum: IC₅₀ = 2.2 nM

Ki 数据 :

Alkaline phosphatase, tissue-nonspecific isozyme: K_i= 16 µM (human); Porcine kidney tissue non-specific alkaline phosphatase : K_i= 93 µM

pK值 :

pK_b: 10 (Predicted)

仅供科研使用。不可用于诊断或治疗。

德国水公害等级 :

RTECS :

NJ5960000

PubChem CID :

27944

默克索引 :

14: 5459

MDL 号码 :

MFCD00012675

EC号码 :

240-654-6

Beilstein 注册 :

4358988

SMILES :

C1CSC2=N[[email protected]](CN21)C3=CC=CC=C3.Cl

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