Skip to main content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Can Fam Physician. 1979 Mar; 25: 317–319.
PMCID: PMC2382988
PMID: 21297691

The HBsAg-Positive Patient: Implications and a Guide to Management

Abstract

Following infection with hepatitis B virus (HBV), hepatitis B surface antigen (HBsAg) is detectable in the serum before liver function tests become abnormal and before development of clinical features of hepatitis; HBsAg tests usually become negative shortly after illness subsides. Screening individuals such as volunteer blood donors for HBsAg occasionally reveals apparently healthy people who are persistent carriers of HBsAg; the majority have no laboratory evidence of hepatitis whereas others have biochemical or histologic findings of chronic liver disease.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (715K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

 
 

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  • BLUMBERG BS, ALTER HJ, VISNICH S. A "NEW" ANTIGEN IN LEUKEMIA SERA. JAMA. 1965 Feb 15;191:541–546. [PubMed] [Google Scholar]
  • Robinson WS, Lutwick LI. The virus of hepatitis, type B (first of two parts). N Engl J Med. 1976 Nov 18;295(21):1168–1175. [PubMed] [Google Scholar]
  • Feinman SV, Berris B, Sinclair JC, Wrobel DW. Practical guidelines for assessing patients positive for hepatitis B surface antigen. Can Med Assoc J. 1976 Nov 20;115(10):991–994. [PMC free article] [PubMed] [Google Scholar]
  • Dienstag JL, Rhodes AR, Bhan AK, Dvorak AM, Mihm MC, Jr, Wands JR. Urticaria associated with acute viral hepatitis type B: studies of pathogenesis. Ann Intern Med. 1978 Jul;89(1):34–40. [PubMed] [Google Scholar]
  • Melnick JL, Dreesman GR, Hollinger FB. Viral hepatitis. Sci Am. 1977 Jul;237(1):44–52. [PubMed] [Google Scholar]
  • Aach RD. Viral hepatitis--A to e. Med Clin North Am. 1978 Jan;62(1):59–70. [PubMed] [Google Scholar]
  • Edgington TS, Chisari FV. Immunological aspects of hepatitis B virus infection. Am J Med Sci. 1975 Sep-Oct;270(2):212–227. [PubMed] [Google Scholar]
  • Aldershvile J, Dietrichson O, Hardt F, Nielsen JO, Skinhöj P. Humoral and cell-mediated immunity to hepatitis B virus antigens in acute and chronic liver disease. Scand J Gastroenterol. 1977;12(8):917–922. [PubMed] [Google Scholar]
  • Alberti A, Diana S, Sculard GH, Eddleston AL, Williams R. Detection of a new antibody system reacting with Dane particles in hepatitis B virus infection. Br Med J. 1978 Oct 14;2(6144):1056–1058. [PMC free article] [PubMed] [Google Scholar]
  • Szmuness W, Much I, Prince AM, Hoofnagle JH, Cherubin CE, Harley EJ, Block GH. On the role of sexual behavior in the spread of hepatitis B infection. Ann Intern Med. 1975 Oct;83(4):489–495. [PubMed] [Google Scholar]
  • Nielsen JO. What shall we do with the HBs Ag carrier? Scand J Gastroenterol. 1976;11(7):641–644. [PubMed] [Google Scholar]
  • Levy BS, Harris JC, Smith JL, Washburn JW, Mature J, Davis A, Crosson JT, Polesky H, Hanson M. Hepatitis B in ward and clinical laboratory employees of a general hospital. Am J Epidemiol. 1977 Oct;106(4):330–335. [PubMed] [Google Scholar]
  • Babb RR. Hepatitis B antigen: a review of its importance in the practice of obstetrics and gynecology. Am J Obstet Gynecol. 1976 Nov 1;126(5):602–606. [PubMed] [Google Scholar]
  • Janzen J, Tripatzis I, Wagner U, Schlieter M, Müller-Dethard E, Wolters E. Epidemiology of hepatitis B surface antigen (HBsAg) and antibody to HBsAg in hospital personnel. J Infect Dis. 1978 Mar;137(3):261–265. [PubMed] [Google Scholar]
  • Berris B, Feinman SV, Sinclair JC, Wrobel D. Hepatitis and hepatitis B surface antigen and antibody in dentists. Can Med Assoc J. 1978 Nov 4;119(9):1040–1043. [PMC free article] [PubMed] [Google Scholar]
  • Tzukert A, Sandler SG. Dental care and spread of hepatitis B virus infection. J Clin Microbiol. 1978 Sep;8(3):302–305. [PMC free article] [PubMed] [Google Scholar]
  • Okada K, Kamiyama I, Inomata M, Imai M, Miyakawa Y. e antigen and anti-e in the serum of asymptomatic carrier mothers as indicators of positive and negative transmission of hepatitis B virus to their infants. N Engl J Med. 1976 Apr 1;294(14):746–749. [PubMed] [Google Scholar]
  • Turner GC, Green HT, Blundell VD. e-Antigen: a link between immune response and infectivity in hepatitis B? J Hyg (Lond) 1978 Dec;81(3):405–414. [PMC free article] [PubMed] [Google Scholar]
  • Grady GF, Lee VA, Prince AM, Gitnick GL, Fawaz KA, Vyas GN, Levitt MD, Senior JR, Galambos JT, Bynum TE, et al. Hepatitis B immune globulin for accidental exposures among medical personnel: final report of a multicenter controlled trial. J Infect Dis. 1978 Nov;138(5):625–638. [PubMed] [Google Scholar]
  • Hieber JP, Dalton D, Shorey J, Combes B. Hepatitis and pregnancy. J Pediatr. 1977 Oct;91(4):545–549. [PubMed] [Google Scholar]
  • Cossart YE. The outcome of hepatitis B virus infection in pregnancy. Postgrad Med J. 1977 Oct;53(624):610–613. [PMC free article] [PubMed] [Google Scholar]
  • Gerety RJ, Schweitzer IL. Viral hepatitis type B during pregnancy, the neonatal period, and infancy. J Pediatr. 1977 Mar;90(3):368–374. [PubMed] [Google Scholar]
  • Larke RP, Haworth JC, Read JH. Breast-feeding by mothers positive for HBsAG. Can Med Assoc J. 1977 Jun 18;116(12):1344–1344. [PMC free article] [PubMed] [Google Scholar]
  • Shiraki K, Yoshihara N, Kawana T, Yasui H, Sakurai M. Hepatitis B surface antigen and chronic hepatitis in infants born to asymptomatic carrier mothers. Am J Dis Child. 1977 Jun;131(6):644–647. [PubMed] [Google Scholar]
  • Fawaz KA, Grady GF, Kaplan MM, Gellis SS. Repetitive maternal-fetal transmission of fatal hepatitis B. N Engl J Med. 1975 Dec 25;293(26):1357–1359. [PubMed] [Google Scholar]
  • Prince AM. Sounding board. Use of hepatitis B immuneglobulin:reassessment needed. N Engl J Med. 1978 Jul 27;299(4):198–199. [PubMed] [Google Scholar]
  • Maynard JE. Passive immunization against hepatitis B: a review of recent studies and comment on current aspects of control. Am J Epidemiol. 1978 Feb;107(2):77–86. [PubMed] [Google Scholar]

Articles from Canadian Family Physician are provided here courtesy of College of Family Physicians of Canada

Feedback hbsag test